Expression of CD34, DOG1, S100 in CD117-negative and CD117-positive gastrointestinal stromal tumors with different potential of malignancy and clinical, morphological features
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چکیده
منابع مشابه
Expression of DOG1, CD117 and PDGFRA in gastrointestinal stromal tumors and correlations with clinicopathology.
OBJECTIVE To discuss the significance of DOG1, CD117 and PDGFRA in the diagnosis of gastrointestinal stromal tumors (GISTs), and analyze their correlations with clinicopathological features and risk ranking. METHOD DOG1, CD117 and PDGFRA were detected with IHC Envision ldpe-g-nvp in 63 GISTs and 43 cases of non-GISTs, and analyzed for relations with clinicopathological factors (gender, age, l...
متن کاملThe significance of KIT (CD117) in gastrointestinal stromal tumors.
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متن کاملExpression of DOG1, PDGFRA, and p16 in Gastrointestinal Stromal Tumors
BACKGROUND/AIMS The diagnosis of gastrointestinal stromal tumors (GIST) relies on the demonstration of KIT expression, but KIT expression is absent or reduced in approximately 15% of GIST. METHODS Eighty-one GISTs were diagnosed between January 1998 and December 2007 at the Department of Pathology at both Chungnam National University Hospital and Eulji University Hospital, Daejeon. Medical hi...
متن کاملDetermination of CD117 Expression in Glial Tumors and Its Comparison between High Grade and Low Grade Tumors
Background and Objective: Gliomas are the most common primary brain tumors. Despite therapeutic advances, the majority of gliomas do not respond to either chemo or radiotherapy. CD117, the gene product of c-kit has been expressed in cells of glial tumors. Because gastrointestinal stromal tumors (GISTs) that express CD117 respond dramatically to treatment with tyrosine kinase inhibitors, ide...
متن کاملA CD117 and CD34 immunoreactive sarcoma masquerading as a gastrointestinal stromal tumor: diagnostic pitfalls of ancillary studies in sarcoma.
BACKGROUND The immunohistochemical hallmarks of gastrointestinal stromal tumors (GISTs) are positivity for CD117 (c-kit) and CD34; however, CD117 is not specific for GISTs, and the list of CD117+ tumors/tissues is increasing. Also, MDM2 is known to be amplified in several types of mesenchymal tumors, including liposarcoma. METHODS We report a spindle cell sarcoma arising in the mediastinum th...
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ژورنال
عنوان ژورنال: Pathologia
سال: 2015
ISSN: 2306-8027
DOI: 10.14739/2310-1237.2015.3.55103